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Updated: Apr 17, 2026
08:20
In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
Published on: December 30, 2016
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FOXP3+ regulatory T cells and their functional regulation
Zhiyuan Li1, Dan Li1, Andy Tsun1,2
1Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Cellular & Molecular Immunology
|February 17, 2015
Summary
Regulatory T (Treg) cells are vital for immune balance. This review explores Treg cell mechanisms and their therapeutic potential in autoimmune diseases, GVHD, and cancer treatment.
Area of Science:
- Immunology
- Cell Biology
Background:
- FOXP3(+) regulatory T (Treg) cells are essential for maintaining immune tolerance and homeostasis.
- Recent research has focused on the molecular mechanisms governing Treg cell stability, plasticity, and function.
Purpose of the Study:
- To summarize recent findings on Treg cell molecular mechanisms.
- To provide insights into the therapeutic applications of Treg cells.
Main Methods:
- Literature review of recent studies on Treg cell biology.
- Analysis of molecular mechanisms of Treg cell stability and plasticity.
Main Results:
- Treg cell stability, plasticity, and functional activity are complex and actively researched.
- Understanding these mechanisms is key to Treg cell manipulation.
Conclusions:
- Treg cell mechanisms offer promising avenues for therapeutic intervention.
- Potential applications include treatment for autoimmune diseases, graft-versus-host disease (GVHD), and cancer.
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