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Updated: Apr 17, 2026
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy
Petra E M van Schie1, Josephine Schijns2, Jules G Becher3
1Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; Department of Physical Therapy, VU University Medical Center, Amsterdam, The Netherlands.
Background:
A cohort of children born with perinatal hypoxic-ischemic encephalopathy (HIE) was followed prospectively until school age.
Aims:
To describe motor outcome and behavioral functioning of school-age children after perinatal HIE and the relationship with neonatal MRI and outcome at age 2.
Methods:
Twenty-five children (19 males), born at term with perinatal HIE, were assessed at a mean age of 7 y 6 m (range 6 y 4 m-8 y 2 m). Motor ability was assessed with the Movement Assessment Battery for Children (2nd version) and behavioral functioning was assessed with the Child Behavior Checklist. Neonatal MRI was scored according to Barkovich classification.
Results:
Of the 25 included children, eight had cerebral palsy (CP). Of the 17 children without CP, nine had impaired motor ability (of which 3 scored definitely abnormal), and four had behavioral problems. There was a significant difference in motor performance (p = 0.008) between children with normal and children with abnormal neonatal MRI. Two (of four) children with normal motor ability and seven (of 14) children with normal neurological examination at age 2 showed impaired motor ability at school age.
Conclusions:
Half of the children without CP had impaired motor ability at school age. A normal outcome after HIE at young age does not necessarily imply a good outcome at school age, even when neonatal MRI does not show any abnormalities. More research is needed on the behavioral and cognitive consequences of HIE at school age and on the consequences for quality of life for children with and without CP.
