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Falsified antimalarials: a minireview.

Carlos Chaccour¹, Harparkash Kaur, Jose Luis Del Pozo

¹Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona 31008, Spain.

Expert Review of Anti-Infective Therapy

|February 17, 2015

Summary

This summary is machine-generated.

Poor quality and falsified antimalarial drugs endanger lives in endemic areas. Combating this requires drug quality surveillance, improved legislation, and better access to affordable antimalarials.

Keywords:

antimalarials artemisinin artesunate counterfeit drugs falsified drugs malaria poor-quality drugs substandard drugs

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Area of Science:

Global Health
Pharmacovigilance
Medicinal Chemistry

Background:

Malaria is a treatable disease requiring effective medications.
Substandard and counterfeit antimalarial drugs pose significant risks to public health in endemic regions.
These poor-quality drugs lead to increased mortality, economic burdens, and erosion of trust in healthcare systems.

Purpose of the Study:

To highlight the public health threat posed by substandard and falsified antimalarial drugs.
To discuss the challenges in assessing the prevalence of poor-quality antimalarials.
To propose strategies for mitigating the impact of counterfeit antimalarial medicines.

Main Methods:

Literature review on the prevalence and impact of poor-quality antimalarials.
Analysis of factors contributing to the trade of falsified medicines.
Examination of current surveillance and regulatory approaches.

Main Results:

The prevalence of poor-quality antimalarials may be as high as 35%, though estimates vary due to methodological differences.
Falsified antimalarials result in treatment failures, drug resistance, and adverse health outcomes.
Economic losses affect patients, families, and the pharmaceutical industry.

Conclusions:

Strengthening drug quality surveillance systems is crucial.
Implementing robust legislation and regulatory frameworks can curb the trade in falsified medicines.
Improving access to and affordability of genuine antimalarial drugs is essential for malaria control.