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Irisin as an exercise-stimulated hormone binding crosstalk between organs
1College of Health Science, Wuhan Sports University, Wuhan, China. liujun@wipe.edu.cn.
European Review for Medical and Pharmacological Sciences
|February 17, 2015
Summary
Irisin, a newly discovered hormone, is upregulated by exercise and impacts various organs. This protein hormone plays a role in treating both inflammation and non-inflammation related diseases.
Area of Science:
- Endocrinology
- Molecular Biology
- Exercise Physiology
Background:
- Irisin is an 112-amino acid glycosylated protein hormone.
- It is upregulated by exercise, mediated by peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α).
- Irisin circulates and targets various organs, influencing diverse physiological processes.
Purpose of the Study:
- To explore the multifaceted roles of irisin in the body.
- To investigate the connection between irisin levels and various diseases.
- To understand the therapeutic potential of exercise-induced irisin.
Main Methods:
- Literature review of studies on irisin.
- Analysis of irisin's molecular pathways.
- Correlation analysis of irisin levels with disease states.
Main Results:
- Irisin promotes osteoblast differentiation.
- It aids in nerve cell and beta-cell regeneration.
- Basal irisin levels are linked to inflammation and non-inflammation related diseases.
- Exercise-induced irisin shows therapeutic benefits.
Conclusions:
- Irisin is a key hormone with diverse physiological functions.
- Irisin levels are associated with various health conditions.
- Exercise-induced irisin holds promise for therapeutic interventions in disease management.
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