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Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
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Highly selective in vivo imaging of endogenous/exogenous phosphate ion over ATP and PPi
Jun Feng Zhang1, Lin E Guo, Tie Nan Zang
1College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500 (China), Fax: (+86) 871-65941088. junfengzhang78@aliyun.com.
Chemistry, an Asian Journal
|February 17, 2015
Abstract:
A chemodosimeter was designed to function as a highly selective phosphate ion (Pi ) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells.
