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Updated: Apr 17, 2026

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
Published on: January 2, 2016
Viral-mediated expression of c-Myc and cyclin A2 induces cochlear progenitor cell proliferation
Cuiping Zhong1, Yu Han2, Ji Ma3
1Department of Otolaryngology, Lanzhou General Hospital of People's Liberation Army, 730050 Lanzhou, China.
Abstract:
Cochlear progenitor cells have a limited proliferative capability, which prevents their application in treating sensorineural hearing loss. In this study, we showed that the expression of c-Myc and cyclin A2 was down-regulated during the development of cochlear tissue and CPC differentiation. Over-expression of these two genes using adenovirus transduction, significantly affected the CPC cell cycle and promoted the CPC proliferation. We further demonstrated that this promotion involves the classic CKI-cyclin-CDK pathway. Our study suggests that genetically modified CPCs may be a promising cell source for cochlear stem cell transplantation that improves the efficacy of cell therapy.
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