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National registry-based case-control study: comorbidity and stroke in young adults

E-M Bergman1, K M Henriksson, S Åsberg

  • 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Acta Neurologica Scandinavica
|February 17, 2015
PubMed

Insights

Comorbidity significantly increases stroke risk in young adults. The more diagnosed conditions, the higher the likelihood of stroke, beyond traditional vascular factors.

Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • Stroke disproportionately affects young adults with chronic diseases.
  • Limited understanding of comorbidity's impact on stroke in younger populations.
  • Need to compare comorbidity prevalence in young stroke patients versus controls.

Purpose of the Study:

  • To investigate the association between comorbidity and stroke in young adults (aged 15-44).
  • To compare comorbidity prevalence in young stroke patients against age- and sex-matched controls.

Main Methods:

  • Utilized a nationwide cohort from the Swedish Stroke Register (2001-2009).
  • Included age- and sex-matched controls from the Swedish Population Register.
  • Analyzed discharge diagnoses using the International Classification of Diseases 10th revision (ICD-10) and multivariable logistic regression.

Main Results:

  • Vascular risk factors (hypertension, dyslipidemia, diabetes) were more prevalent in stroke patients.
  • Eight ICD-10 chapters (neoplasms, blood, endocrine, psychiatric, nervous, eye, circulatory, symptoms) showed independent associations with stroke.
  • Stroke risk increased by 26% for each additional diagnosed ICD-10 chapter.

Conclusions:

  • Comorbidity, beyond vascular risk factors, is linked to an elevated stroke risk in young individuals.
  • The number of diagnosed comorbidities directly correlates with increased stroke risk.
  • Highlights the importance of managing overall health in preventing stroke among young adults.
Abstract

Keywords:
cerebrovascular diseasestrokes

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