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Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters
Zhong Liu1, Xin-Mei Wang, Tong-Fu Jia
1Medical College, Qingdao University, Qingdao, China
Background:
Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters.
Materials And Methods:
Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens.
Results:
A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor.
Conclusions:
This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.
