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Related Experiment Videos

Diamorphine stability in aqueous solution for subcutaneous infusion.

O A Omar1, P J Hoskin, A Johnston

  • 1Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK.

The Journal of Pharmacy and Pharmacology
|April 1, 1989
PubMed
Summary

Diamorphine hydrochloride degrades slowly at 4 degrees C and above, forming 6-monoacetylmorphine and morphine. Higher concentrations also show precipitation and turbidity, impacting drug stability.

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Area of Science:

  • Pharmaceutical Chemistry
  • Drug Stability Studies

Background:

  • Diamorphine hydrochloride is a potent opioid analgesic.
  • Understanding its stability is crucial for safe and effective clinical use.

Purpose of the Study:

  • To investigate the influence of temperature and concentration on diamorphine hydrochloride stability.
  • To determine degradation pathways and identify factors affecting drug integrity over time.

Main Methods:

  • Diamorphine hydrochloride solutions at various concentrations were stored at -20, 4, 21, and 37 degrees C for 8 weeks.
  • High-performance liquid chromatography (HPLC) was used to quantify diamorphine, 6-monoacetylmorphine, and morphine at different time points.

Main Results:

  • Slow degradation of diamorphine was observed at temperatures of 4 degrees C and above.

Related Experiment Videos

  • Degradation products included 6-monoacetylmorphine and morphine, with a corresponding decrease in pH and development of an acetic acid odor.
  • Precipitation and turbidity occurred in solutions of 15.6 mg mL-1 and higher after 2 weeks.

    • Conclusions:

    • Temperature significantly impacts diamorphine hydrochloride stability, with degradation accelerating at 4 degrees C and above.
    • Concentration plays a role in physical stability, leading to precipitation and turbidity at higher levels.
    • These findings highlight the importance of controlled storage conditions for diamorphine hydrochloride to maintain its quality and efficacy.