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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Controlled Drug Release from Pharmaceutical Nanocarriers.

Jinhyun Hannah Lee1, Yoon Yeo2

  • 1College of Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Chemical Engineering Science
|February 17, 2015
PubMed
Summary

Controlled drug release using nanocarriers enhances therapeutic efficacy and reduces toxicity. This review details nanocarrier drug release mechanisms and control strategies for optimized delivery systems.

Keywords:
Nanocarrierscontrolled releasedrug deliverydrug release kineticsdrug release mechanisms

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Pharmaceutical Sciences

Background:

  • Nanocarriers offer spatiotemporal control over drug release, crucial for minimizing toxicity and maximizing therapeutic outcomes.
  • The high surface area-to-volume ratio and short diffusion distances present unique challenges for controlling nanocarrier drug release kinetics.

Purpose of the Study:

  • To review drug release mechanisms from nanocarriers.
  • To explore various nanocarrier types and their properties.
  • To emphasize strategies for controlling drug release kinetics for targeted applications.

Main Methods:

  • Literature review of nanocarrier drug release mechanisms.
  • Analysis of carrier composition and morphology effects on release kinetics.
  • Overview of current nanocarrier preparation and modification techniques.

Main Results:

  • Understanding drug retention and release mechanisms is key to designing effective nanocarriers.
  • Carrier composition and morphology significantly influence drug release profiles.
  • Various techniques exist for preparing and modifying nanocarriers to tailor release kinetics.

Conclusions:

  • Effective control of drug release kinetics is essential for advanced nanocarrier-based therapies.
  • Further research into nanocarrier design and modification can lead to improved drug delivery systems.
  • This review provides a comprehensive overview for developing nanocarriers with predictable and desirable release characteristics.