Aortopathy associated with congenital heart disease: A current literature review
1Department of Cardiac Surgery, University Hospital Gent, De Pintelaan, Gent, Belgium.
Annals of Pediatric Cardiology
|February 17, 2015
Insights
Congenital heart disease (CHD) often leads to aortic dilatation. This review covers the causes, progression, and management of aortic disease in CHD patients.
Area of Science:
- Cardiology
- Vascular Biology
- Genetics
Background:
- Aortic dilatation is common in patients with congenital heart disease (CHD).
- It occurs both at initial diagnosis and after surgical repair.
- This condition, known as aortopathy, requires careful monitoring.
Purpose of the Study:
- To review the pathologies linked to aortopathy in CHD.
- To discuss the current understanding of the pathophysiology and evolution of aortic disease in CHD.
- To outline current treatment guidelines for aortic disease in the context of CHD.
Main Methods:
- Literature review of pathologies associated with aortopathy in CHD.
- Synthesis of current knowledge on the pathophysiology and natural history of aortic disease in CHD.
- Analysis of existing treatment guidelines for aortic disease in CHD patients.
Main Results:
- Aortopathy is a frequent complication in various forms of CHD.
- Pathophysiological mechanisms involve genetic, molecular, and biomechanical factors.
- Management strategies are evolving, focusing on risk stratification and tailored interventions.
Conclusions:
- Understanding aortopathy in CHD is crucial for timely diagnosis and management.
- Multidisciplinary approaches are essential for optimizing patient outcomes.
- Further research is needed to refine treatment strategies and improve long-term prognosis.
Abstract:
In patients born with congenital heart disease, dilatation of the aorta is a frequent feature at presentation and during follow-up after surgical intervention. This review provides an overview of the pathologies associated with aortopathy, and discusses the current knowledge on pathophysiology, evolution, and treatment guidelines of the aortic disease associated with congenital heart defects.
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