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New parameter in diagnosis of acute appendicitis: platelet distribution width
Bulent Dinc1, Alten Oskay1, Selcan Enver Dinc1
1Bulent Dinc, Department of General Surgery, Ataturk State Hospital, Antalya 07040, Turkey.
World Journal of Gastroenterology
|February 17, 2015
Summary
Platelet distribution width is a reliable indicator for diagnosing acute appendicitis. This simple blood test offers high accuracy, reducing costs and saving time in diagnosis.
Area of Science:
- Hematology
- Diagnostic Medicine
- Surgical Pathology
Background:
- Acute appendicitis diagnosis relies on clinical evaluation and laboratory tests.
- Novel biomarkers are needed to improve diagnostic accuracy and efficiency.
Purpose of the Study:
- To evaluate the diagnostic accuracy of mean platelet volume (MPV) and platelet distribution width (PDW) in acute appendicitis.
- To compare MPV and PDW with traditional inflammatory markers.
Main Methods:
- Retrospective case-controlled study involving 295 acute appendicitis patients, 100 with other intra-abdominal infections, and 100 healthy controls.
- Comparison of demographic data, white blood cell count, neutrophil percentage, MPV, and PDW.
- Calculation of sensitivity, specificity, predictive values, and diagnostic accuracy.
Main Results:
- Platelet distribution width (PDW) showed significantly higher values in acute appendicitis patients compared to controls (P < 0.05).
- PDW demonstrated high diagnostic accuracy (96.0%) for acute appendicitis, surpassing MPV and comparable to white blood cell count and neutrophil percentage.
- The highest diagnostic accuracy was observed for PDW when comparing acute appendicitis patients to healthy individuals (P < 0.01).
Conclusions:
- Platelet distribution width is a sensitive and specific biomarker for diagnosing acute appendicitis.
- PDW analysis offers a cost-effective and time-efficient diagnostic tool for acute appendicitis.
- No additional tests are required when utilizing PDW for acute appendicitis diagnosis.
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