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Cultured composite skin grafts: biological skin equivalents permitting massive expansion
J Nanchahal1, W R Otto, R Dover
1Department of Anatomy, Charing Cross and Westminster Medical School, London, UK.
Lancet (London, England)
|July 22, 1989
Abstract:
After assessment in mice, a biological skin equivalent consisting of cultured fibroblasts in a collagen gel overlain with cultured keratinocytes was applied to three patients who had had tattoos excised. In all patients the grafts took well with good cosmetic results and little or no contracture. A biopsy at 4 weeks showed that the central graft area had a fully differentiated epidermis and a mature dermis without adnexae.