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Does Sickle Cell Disease Protect Against Diabetes Mellitus?: Cross-sectional study

Ali A Suwaidan1, Fathia Al-Qurashi2, David L Whitford3

  • 1School of Medicine, Royal College of Surgeons in Ireland Medical University of Bahrain, Busaiteen, Bahrain.

Sultan Qaboos University Medical Journal
|February 17, 2015
PubMed

Insights

The prevalence of diabetes mellitus (DM) in sickle cell disease (SCD) patients in Bahrain was 8.3%. Although high, this rate is lower than anticipated, suggesting SCD may offer some protection against DM.

Area of Science:

  • Hematology
  • Endocrinology
  • Public Health

Background:

  • Co-existence of diabetes mellitus (DM) and sickle cell disease (SCD) is uncommon.
  • Bahrain has a high prevalence of DM, making the DM rate in SCD patients a significant public health question.

Purpose of the Study:

  • To determine the prevalence of DM in adult SCD patients in Bahrain.
  • To compare DM prevalence in SCD patients to the general population.

Main Methods:

  • Cross-sectional study of 2,204 adult SCD patients from 2003-2010.
  • DM prevalence assessed via laboratory records in a random sample of 520 patients.

Main Results:

  • 24 out of 376 SCD patients (6.4%) had DM.
  • Age- and sex-standardized DM prevalence was 8.3% in the SCD cohort.

Conclusions:

  • DM prevalence in Bahraini SCD patients is high but lower than expected.
  • Sickle cell disease might confer a protective effect against DM development.
  • Concurrent DM and SCD necessitate screening and aggressive management due to vascular disease risks.
Abstract

Keywords:
BahrainComorbidityDiabetes MellitusEpidemiologyPrevalenceSickle Cell DiseaseVascular Diseases

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