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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Hepatitis01:25

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Arboviral Encephalitis01:25

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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Dengue and its effects on liver.

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Dengue virus infection can cause liver damage, leading to abnormal liver function tests and, rarely, acute liver failure. This review explores dengue

Keywords:
Acute liver failureBilirubinDengueLiverTransaminasesViral hepatitis

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Area of Science:

  • * Virology
  • * Hepatology
  • * Infectious Diseases

Background:

  • * Dengue is a significant arboviral disease prevalent in tropical regions, transmitted by Aedes mosquitoes.
  • * Hepatotoxicity is a recognized complication of dengue virus infection.
  • * Liver function test abnormalities are common in dengue patients.

Purpose of the Study:

  • * To review the hepatic manifestations associated with dengue virus infection.
  • * To discuss the underlying pathogenesis of liver injury in dengue.
  • * To highlight dengue as a cause of acute liver failure in endemic areas.

Main Methods:

  • * Comprehensive literature review of studies on dengue and liver injury.
  • * Analysis of clinical data and case reports concerning hepatic manifestations in dengue.
  • * Examination of virological and immunological mechanisms contributing to dengue-induced liver damage.

Main Results:

  • * Common hepatic derangements include elevated bilirubin, transaminases, and altered albumin levels.
  • * Jaundice and acute liver failure (ALF) are rare but serious complications of dengue.
  • * Dengue is a leading cause of ALF in dengue-endemic countries.

Conclusions:

  • * Dengue virus infection frequently impacts liver function.
  • * Understanding the pathogenesis of liver injury is crucial for managing severe dengue cases.
  • * Dengue should be considered in the differential diagnosis of acute liver injury in endemic regions.