Related Experiment Video
Updated: Apr 17, 2026
08:03
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
428
Distribution, Severity and Radiologic Features of Intracranial Stenosis in Asymptomatic Pakistanis
Ayeesha K Kamal1, Farzin Majeed2, Muhammad S Ilyas3
1Department of Neurology and Stroke Service, Aga Khan University, Pakistan.
Austin Journal of Cerebrovascular Disease & Stroke
|February 17, 2015
Summary
Asymptomatic intracranial atherosclerotic disease (ICAD) is common in young Pakistanis, affecting 34.5% of individuals. This condition often impacts the posterior circulation and is linked to periventricular lucencies.
Area of Science:
- Neurology
- Radiology
- Vascular Medicine
Background:
- Intracranial atherosclerotic disease (ICAD) is a leading global cause of ischemic stroke.
- ICAD represents a significant portion of ischemic strokes, particularly in Asian populations.
Purpose of the Study:
- To determine the prevalence of asymptomatic ICAD in a Pakistani population.
- To identify associated findings on Magnetic Resonance Imaging (MRI).
Main Methods:
- 200 adults without stroke symptoms were recruited.
- Participants underwent MRI on a 1.5 Tesla scanner.
- Intracranial arteries were assessed for atherosclerotic disease using specialized software.
Main Results:
- Asymptomatic ICAD was present in 34.5% of subjects.
- The posterior cerebral artery was the most commonly affected vessel.
- Periventricular lucencies were significantly associated with asymptomatic ICAD.
Conclusions:
- Asymptomatic ICAD is prevalent in young Pakistanis, with no gender bias.
- Posterior circulation is preferentially affected by ICAD.
- Silent brain infarcts are less common than other MRI findings like atrophy and periventricular lucencies.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
559
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
559
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
504
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
504
01:26Aneurysm III: Interprofessional Care
463
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
463
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
943
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
943
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
715
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
715
01:20Imaging Studies for Cardiovascular System III: X-Ray
692
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
692