Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.2K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.2K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

2.8K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.8K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.7K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.7K
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

2.4K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
2.4K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

2.0K
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
2.0K
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

1.7K
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gifts, Blind Spots, and Gray: Canadian Student Pharmacists' Perceptions of Pharmaceutical Industry Interactions.

American journal of pharmaceutical education·2026
Same author

Drug Coverage Policy and Legacy Prescribing: A Cross-Sectional Analysis in British Columbia.

Health science reports·2026
Same author

Sustainability pharmacy assistants in large urban hospital system.

The International journal of pharmacy practice·2026
Same author

Rising Escitalopram Use in British Columbia: Is it Rational and Evidence-Informed?

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2025
Same author

Pharmacotherapy for hypertension in adults 60 years or older.

The Cochrane database of systematic reviews·2025
Same author

Is bigger better? Analysis of efficacy and safety of lemborexant 5 versus 10 mg in insomnia patients.

The International journal of pharmacy practice·2025
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
07:59

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

11.9K

Loop diuretics for patients receiving blood transfusions.

Michael Sarai1, Aaron M Tejani

  • 1College of Medicine, Kansas City University of Medicine & Biosciences, 1750 E Independence Ave, Kansas City, Missouri, USA.

The Cochrane Database of Systematic Reviews
|February 17, 2015
PubMed
Summary
This summary is machine-generated.

Prophylactic loop diuretics are commonly given during blood transfusions, but evidence is lacking to support their use. More research is needed to determine if these diuretics offer a therapeutic advantage in preventing transfusion-related complications.

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.5K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.7K

Related Experiment Videos

Last Updated: Apr 17, 2026

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
07:59

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

11.9K
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.5K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.7K

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Blood transfusions carry risks of morbidity and mortality.
  • Prophylactic loop diuretics are frequently administered to mitigate transfusion-related risks like circulatory overload and pulmonary edema.

Purpose of the Study:

  • To evaluate the therapeutic advantage of prophylactic loop diuretics in blood transfusion recipients.
  • To determine the risk-benefit ratio of using loop diuretics versus placebo or fluid restriction.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) and quasi-RCTs.
  • Searched Cochrane Renal Group's Specialized Register.
  • Data extraction and quality assessment by two independent authors.

Main Results:

  • Four studies with 100 participants were included; furosemide was the only diuretic studied.
  • No studies assessed clinically important transfusion-related outcomes.
  • One study showed improved fraction of inspired oxygen with furosemide; two showed improved pulmonary capillary wedge pressure.

Conclusions:

  • Insufficient evidence exists to confirm the benefit of prophylactic loop diuretics in preventing transfusion-related morbidity.
  • Well-conducted RCTs are urgently needed to establish the therapeutic utility of pre-transfusion loop diuresis.
  • Current practice of prophylactic loop diuretic use during transfusions lacks supporting evidence.