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[Biotransformation of B 24/76 in the rat, minipig, dog and man]
A Baumann1, R Seefeld, I Werner
1Institut für Pharmakologie und Toxikologie, Ernst-Moritz-Arndt-Universität Griefswald.
Die Pharmazie
|March 1, 1989
Abstract:
After oral administration of B 24/76 (1) on experimental animals (rat, minipig, dog) and human beings 11 metabolites could be isolated from urine, faeces and bile. The structure of 7 compounds was elucidated by means of TLC and MS. The investigated species are showing an analogues metabolic pattern with differences in the intensity and main metabolites. In phase II-reaction we could observe qualitative differences.