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Neuroleptic-induced persistent "open mouth".

S Priebe1, H P Stahl, R Deymann

  • 1Department of Psychiatry, Free University of Berlin, FRG.

Pharmacopsychiatry
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

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A patient developed a persistent, unusual motor disturbance, characterized by an open mouth, after long-term exposure to butyrophenones. This extrapyramidal symptom persisted even after medication cessation, with no other cause identified.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Butyrophenones are a class of antipsychotic medications.
  • Prolonged exposure to neuroleptics can lead to extrapyramidal motor disturbances.
  • Paranoid psychosis is a severe mental disorder.

Observation:

  • A patient with paranoid psychosis exhibited an unusual extrapyramidal motor disturbance.
  • The disturbance involved the patient involuntarily keeping their mouth wide open continuously.
  • This symptom persisted long after the cessation of butyrophenone medication.

Findings:

  • The observed motor disturbance was phenomenologically unusual.
  • No alternative etiological factors for the symptom were identified.
  • The symptom was directly linked to prolonged butyrophenone exposure.

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Implications:

  • This case highlights the potential for persistent and unusual extrapyramidal side effects from butyrophenones.
  • Understanding such prolonged neuroleptic-induced movement disorders is crucial for patient management.
  • Further research into the neurobiological mechanisms underlying persistent extrapyramidal symptoms is warranted.