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Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
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Serum NSE level and disability progression in multiple sclerosis.

Marcus W Koch1, Suzanne George2, Winona Wall2

  • 1Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

Journal of the Neurological Sciences
|February 18, 2015
PubMed
Summary

Serum neuron specific enolase (NSE) is not a reliable biomarker for multiple sclerosis (MS) progression in most forms. However, it showed potential correlations in primary progressive MS, warranting further research.

Keywords:
BiomarkerDisabilityMultiple sclerosisProgressionProgressive MSSerum biomarker

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Clinical Neurology

Background:

  • Previous research indicated serum neuron specific enolase (NSE) as a potential biomarker for multiple sclerosis (MS) progression.
  • The utility of NSE in different MS disease courses remains to be fully elucidated.

Purpose of the Study:

  • To investigate the association of serum NSE levels with different multiple sclerosis (MS) disease courses.
  • To evaluate NSE as a prognostic biomarker in relapsing-remitting (RRMS), secondary progressive (SPMS), and primary progressive MS (PPMS).

Main Methods:

  • Serum NSE levels were measured in 385 MS patients across various disease courses.
  • Correlations between NSE, Expanded Disability Status Scale (EDSS), and MS Severity Score (MSSS) were analyzed.
  • Multiple linear regression identified predictors of serum NSE.

Main Results:

  • Age was the sole independent predictor of serum NSE levels in the overall cohort.
  • In PPMS patients, serum NSE showed moderate correlations with increasing MSSS and EDSS scores.
  • No significant association was found between serum NSE and disease progression in RRMS or SPMS.

Conclusions:

  • Serum NSE is not supported as a prognostic biomarker for RRMS or SPMS.
  • The observed correlations in PPMS require validation in larger, independent cohorts.
  • Further research is needed to confirm the potential role of NSE in PPMS progression.