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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Indications for apheresis as an ultima ratio treatment of refractory hyperlipidemias

P Grützmacher1, C Kleinert, C Dorbath

  • 1Medizinische Klinik II, AGAPLESION Markus Krankenhaus Nephrologie, Hochdruck- und Gefäßkrankheiten, Wilhelm-Epstein-Straße 4, 60431, Frankfurt am Main, Germany, Peter.Gruetzmacher@fdk.info.

Clinical Research in Cardiology Supplements
|February 18, 2015
PubMed

Lipid apheresis is at present well established in routine treatment of diverse hyperlipoproteinemias refractory to conventional dietary and medical regimens, especially in countries with high medical and socioeconomic standards. Severe familial hypercholesterolemia with atherosclerotic vessel disease involving the coronary arteries is the most frequent indication for lipid apheresis as well as homozygous familial hypercholesterolemia before the development of cardiovascular complications.In hyperlipoproteinemia (a) with progressive vessel disease, lipid apheresis is regularly accepted in Germany. The indication of apheresis in Refsum's disease and the chylomicronemia syndrome is described.

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