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Related Experiment Video

Updated: Apr 17, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Calcium phosphate bone cements for local vancomycin delivery.

Dagnija Loca1, Marina Sokolova1, Janis Locs1

  • 1Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of Riga Technical University, Pulka 3, LV-1007 Riga, Latvia.

Materials Science & Engineering. C, Materials for Biological Applications
|February 18, 2015
PubMed
Summary
This summary is machine-generated.

Calcium phosphate bone cements (CPCs) were modified with vancomycin-loaded microcapsules. Novel hydroxyapatite-coated microcapsules significantly improved vancomycin release over 43 days for enhanced bone infection treatment.

Keywords:
Calcium phosphate cementDrug deliveryMicrospheresPLAVancomycin

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopedic Surgery

Background:

  • Calcium phosphate bone cements (CPCs) offer self-setting and injectability for minimally invasive surgery.
  • Surgical procedures risk inflammation and infection, necessitating effective local drug delivery.
  • Systemic antibiotic therapy has disadvantages; local delivery from CPCs can overcome these.

Purpose of the Study:

  • To develop modified CPCs for controlled release of vancomycin.
  • To investigate the effect of poly(lactic acid) (PLA) microcapsules on vancomycin release kinetics.
  • To enhance vancomycin bioavailability using novel PLA/vancomycin microcapsules coated with hydroxyapatite.

Main Methods:

  • Preparation of α-tricalcium phosphate based CPCs.
  • Modification of CPCs with vancomycin-loaded PLA microcapsules.
  • Further modification using PLA/vancomycin microcapsules coated with nanosized hydroxyapatite.

Main Results:

  • Decreasing CPC solid to liquid ratio increased vancomycin burst release.
  • PLA microcapsules reduced initial vancomycin burst release to 7.7±0.6%.
  • Hydroxyapatite-coated microcapsules achieved 85.3±3.1% vancomycin release over 43 days.

Conclusions:

  • CPC modification with PLA microcapsules effectively controls vancomycin release.
  • Novel hydroxyapatite-coated microcapsules enhance vancomycin bioavailability and sustained release.
  • These modified CPCs show promise for preventing bone infection and inflammation in orthopedic procedures.