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Updated: Apr 17, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Calcium supplements controversy in osteoporosis: a physiological mechanism supporting cardiovascular adverse effects
Karolina Paziana1, Michael Pazianas
1John Hopkins Hospital, Baltimore, USA, kpazian1@jhmi.edu.
Abstract:
Recently, administration of calcium supplements for the prevention and treatment of osteoporosis has become a highly controversial issue. The findings of epidemiological studies are not necessarily supportive of the practice and are also open to different interpretations. In this article, we attempt to broaden the discussion and provide evidence that calcium supplementation may fail to compensate for renal calcium loss, and also that the resultant increased calcium load in the circulation could lead to extraskeletal deposition, including in the coronary arteries.
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