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Long-term prognosis of idiopathic nephrotic syndrome in children

Sare Gülfem Özlü1, Gülay Demircin, Nazan Tökmeci

  • 1Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital , Ankara , Turkey and.

Renal Failure
|February 18, 2015
PubMed

Insights

Idiopathic nephrotic syndrome (INS) in children is often steroid-responsive, particularly minimal change disease (MCD). However, focal segmental glomerulosclerosis (FSGS) indicates steroid resistance and potential chronic kidney disease (CKD).

Area of Science:

  • Pediatric Nephrology
  • Internal Medicine
  • Clinical Research

Background:

  • Idiopathic nephrotic syndrome (INS) is a significant kidney disorder in children.
  • Understanding prognostic factors is crucial for managing INS outcomes.

Purpose of the Study:

  • To analyze demographic, clinical, and laboratory data of children with INS.
  • To identify factors influencing the clinical prognosis of pediatric INS patients.

Main Methods:

  • Retrospective analysis of 372 children with INS diagnosed between 1990-2008.
  • Evaluation of demographic, clinical, laboratory findings, treatment protocols, and prognosis.

Main Results:

  • 80.4% of patients were steroid-responsive; 19.6% were steroid-resistant.
  • Focal segmental glomerulosclerosis (FSGS) was linked to steroid resistance, while minimal change disease (MCD) showed higher steroid sensitivity.
  • Complete remission rates were 96% for steroid-sensitive and 46.6% for steroid-resistant cases; 15% of steroid-resistant patients developed chronic kidney disease (CKD).

Conclusions:

  • Steroid therapy response and intercurrent infections are key prognostic indicators in pediatric INS.
  • Early identification of steroid resistance, especially in FSGS cases, is vital for preventing CKD progression.
Abstract

Keywords:
Childrennephrotic syndromeprognosissteroid resistancesteroid sensitive

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