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Related Experiment Video

Updated: Apr 17, 2026

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats
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Triptolide Protects Against Ischemic Stroke in Rats.

Maolin Hao1, Xianghua Li, Jianli Feng

  • 1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, #4 Duanxing West Road, Jinan, 250022, Shandong, China, hao_maolin@163.com.

Inflammation
|February 18, 2015
PubMed
Summary

Triptolide demonstrates neuroprotective effects against ischemic stroke by reducing neuronal damage and inflammation. This natural compound inhibits key inflammatory pathways, offering a potential therapeutic strategy for stroke treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Inflammatory response is a key factor in ischemic stroke pathogenesis.
  • Anti-inflammatory agents are potential therapeutic options for stroke.

Purpose of the Study:

  • To investigate the neuroprotective effects of triptolide in vitro and in vivo.
  • To elucidate the underlying molecular mechanisms of triptolide's action.

Main Methods:

  • In vitro: SH-SY5Y cells subjected to oxygen-glucose deprivation (OGD) or TNF-α stimulation, treated with triptolide.
  • In vivo: Rats underwent middle cerebral artery occlusion (MCAO) followed by reperfusion, treated with triptolide.
  • Assessed cytotoxicity, apoptosis, NF-κB and p38MAPK activation, neurological deficit, infarct volume, and brain water content.

Main Results:

  • Triptolide reduced OGD-induced cytotoxicity and apoptosis in neuronal cells.
  • Triptolide inhibited TNF-α-induced NF-κB and p38MAPK activation in vitro.
  • Triptolide treatment attenuated neurological deficits, brain infarct volume, and brain water content in MCAO rats.
  • Triptolide inhibited NF-κB and p38MAPK activation in the ischemic brains of rats.

Conclusions:

  • Triptolide exhibits significant neuroprotective effects against ischemic cerebral injury.
  • Triptolide exerts its protective effects by inhibiting the NF-κB and p38MAPK signaling pathways.
  • Triptolide represents a promising therapeutic candidate for treating ischemic stroke.