Related Experiment Video

Updated: Apr 17, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.8K

ATM protein kinase signaling, type 2 diabetes and cardiovascular disease

Yolandi Espach1, Amanda Lochner, Hans Strijdom

  • 1Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa, yespach1@gmail.com.

Cardiovascular Drugs and Therapy
|February 18, 2015
PubMed

Insights

Ataxia-telangiectasia mutated (ATM) kinase, known for DNA repair, also impacts cytoplasmic processes linked to cardiovascular disease. Targeting ATM may offer novel therapeutic strategies for heart conditions.

Area of Science:

  • Molecular Biology
  • Cardiovascular Science
  • Genetics

Background:

  • The ataxia-telangiectasia mutated (ATM) protein kinase is primarily recognized for its role in nuclear DNA double-strand break repair.
  • Emerging evidence indicates ATM's involvement in various cytoplasmic functions.
  • Dysregulation of these cytoplasmic ATM functions is implicated in metabolic and cardiovascular complications.

Purpose of the Study:

  • To review the current understanding of ATM's role in the cardiovascular system.
  • To highlight ATM's involvement in oxidative stress, atherosclerosis, metabolism, insulin resistance, and cardiac remodeling.
  • To explore the potential of therapeutic ATM activation for cardiovascular disease prevention and treatment.

Main Methods:

  • Literature review of studies investigating ATM in cardiovascular contexts.
  • Analysis of research on ATM's influence on oxidative stress pathways.
  • Examination of studies linking ATM to metabolic regulation and cardiac structure.

Main Results:

  • ATM plays a role in cellular responses to oxidative stress, a key factor in cardiovascular disease.
  • ATM influences metabolic processes, including insulin resistance.
  • ATM signaling is associated with cardiac remodeling, affecting heart structure and function.

Conclusions:

  • ATM has a multifaceted role in the cardiovascular system beyond its nuclear DNA repair functions.
  • ATM's involvement in oxidative stress, metabolism, and cardiac remodeling suggests its potential as a therapeutic target.
  • Further research into ATM's cardiovascular functions could lead to novel treatments for heart disease.

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

743
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.7K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.9K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.6K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
9.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
5.1K