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Related Experiment Videos

Iotrolan, a nonionic dimeric contrast medium in myelography.

S Bien, M Schumacher, W Berger

    Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. Erganzungsband
    |January 1, 1989
    PubMed
    Summary

    Iotrolan demonstrated significantly better patient tolerance than iohexol in a Phase III clinical trial for myelography contrast media. Opacification was comparable between the two nonionic dimeric contrast agents.

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    Area of Science:

    • Radiology
    • Clinical Trials
    • Medical Imaging

    Background:

    • Nonionic dimeric contrast media are used in myelography.
    • Iotrolan and iohexol are nonionic dimeric contrast agents.
    • Evaluating contrast media involves assessing opacification and patient tolerance.

    Purpose of the Study:

    • To compare the efficacy and safety of iotrolan versus iohexol.
    • To assess differences in opacification and patient tolerance after myelography.
    • To examine electroencephalogram effects of iotrolan and iohexol.

    Main Methods:

    • Phase III, double-blind, comparative clinical study.
    • Two concentrations of iotrolan (240 mg I/ml and 300 mg I/ml) were compared to iohexol.
    • Patients underwent lumbar, thoracic, or cervical myelography.

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    Main Results:

    • Opacification in the subarachnoid space was comparable between iotrolan and iohexol.
    • Patient tolerance was significantly better for iotrolan compared to iohexol.
    • Statistical significance for tolerance difference was p < 0.001 (240 mg I/ml) and p +/- 0.05 (300 mg I/ml).

    Conclusions:

    • Iotrolan is a well-tolerated contrast medium for myelography.
    • Iotrolan offers comparable opacification to iohexol.
    • Iotrolan represents a favorable alternative to iohexol in myelography procedures.