Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iotrolan, a nonionic dimeric contrast medium in myelography.

S Bien, M Schumacher, W Berger

    Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. Erganzungsband
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accurate variance estimation for prevalence ratios.

    Methods of information in medicine·2007
    Same author

    Quantifying the predictive performance of prognostic models for censored survival data with time-dependent covariates.

    Biometrics·2007
    Same author

    The use of imperfect diagnostic tests had an impact on prevalence estimation.

    Journal of clinical epidemiology·2007
    Same author

    The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries.

    Brain research reviews·2007
    Same author

    Validation of surveillance in the intensive care unit component of the German nosocomial infections surveillance system.

    Infection control and hospital epidemiology·2007
    Same author

    Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry.

    Endocrinology·2007

    Iotrolan demonstrated significantly better patient tolerance than iohexol in a Phase III clinical trial for myelography contrast media. Opacification was comparable between the two nonionic dimeric contrast agents.

    Area of Science:

    • Radiology
    • Clinical Trials
    • Medical Imaging

    Background:

    • Nonionic dimeric contrast media are used in myelography.
    • Iotrolan and iohexol are nonionic dimeric contrast agents.
    • Evaluating contrast media involves assessing opacification and patient tolerance.

    Purpose of the Study:

    • To compare the efficacy and safety of iotrolan versus iohexol.
    • To assess differences in opacification and patient tolerance after myelography.
    • To examine electroencephalogram effects of iotrolan and iohexol.

    Main Methods:

    • Phase III, double-blind, comparative clinical study.
    • Two concentrations of iotrolan (240 mg I/ml and 300 mg I/ml) were compared to iohexol.
    • Patients underwent lumbar, thoracic, or cervical myelography.

    Related Experiment Videos

    Main Results:

    • Opacification in the subarachnoid space was comparable between iotrolan and iohexol.
    • Patient tolerance was significantly better for iotrolan compared to iohexol.
    • Statistical significance for tolerance difference was p < 0.001 (240 mg I/ml) and p +/- 0.05 (300 mg I/ml).

    Conclusions:

    • Iotrolan is a well-tolerated contrast medium for myelography.
    • Iotrolan offers comparable opacification to iohexol.
    • Iotrolan represents a favorable alternative to iohexol in myelography procedures.