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Updated: Oct 13, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
10:14

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Published on: May 16, 2014

Pharmacokinetics of iohexol, iopamidol, iopromide, and iosimide compared with meglumine diatrizoate

P Hartwig, W Mützel, V Taenzer

    Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. Erganzungsband
    |January 1, 1989
    PubMed

    Four nonionic contrast media (iohexol, iopamidol, iopromide, and iosimide) are compared in this clinical study in their pharmacokinetic behavior with an ionic reference preparation (meglumine diatrizoate). At a dose of 1 ml of contrast medium per kilogram of body weight with approximately the same iodine content, virtually no differences could be established in the pharmacokinetic behavior. The osmotic diuresis of the ionic substance, compared with that of the nonionic preparations--implies an increased osmotic diuresis, thus, a lower maximal iodine concentration in the urine. The elderly patients included in this study have a reduced glomerular filtration rate, which in turn implies a prolonged half-life in the blood and a retarded renal elimination.

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