Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

15.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
15.5K
Complement System01:27

Complement System

13.1K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
13.1K
Surface Membrane Barriers01:18

Surface Membrane Barriers

3.6K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.6K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

11.6K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
11.6K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

1.6K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.6K
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

94
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
94

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-dimensional ex-vivo visualization of normal and inflamed small intestine and colonic tissue using optical coherence tomography.

Scientific reports·2026
Same author

Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn's Disease.

Digestive diseases and sciences·2026
Same author

Investigating diet to control asparagine uptake as an adjunct to asparaginase treatment.

Frontiers in oncology·2026
Same author

Nutritional Status, Body Composition and Growth in Paediatric-Onset Ulcerative Colitis: A Systematic Review.

Nutrients·2026
Same author

Chronic nonbacterial osteomyelitis associated with pediatric inflammatory bowel disease: A multicenter retrospective study from the Paediatric inflammatory bowel disease Porto Group of ESPGHAN.

Journal of pediatric gastroenterology and nutrition·2025
Same author

Compact fiber-coupled narrowband two-mode squeezed light source.

Optics letters·2025

Related Experiment Video

Updated: Apr 17, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.2K

Do antimicrobial peptides and complement collaborate in the intestinal mucosa?

Zoë A Kopp1, Umang Jain1, Johan Van Limbergen2

  • 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University , Halifax, NS , Canada.

Frontiers in Immunology
|February 18, 2015
PubMed
Summary

The intestines use antimicrobial peptides (AMPs) and complement systems for defense. This study explores their potential cross-talk in maintaining gut health and fighting infections.

Keywords:
Paneth cellanaphylatoxinantimicrobial peptidecathelicidincolitisdefensinintestinelectin pathway

More Related Videos

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

13.0K
Production and Testing of Antimicrobial Peptides and Their Mimics
10:32

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

259

Related Experiment Videos

Last Updated: Apr 17, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.2K
Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

13.0K
Production and Testing of Antimicrobial Peptides and Their Mimics
10:32

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

259

Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • The intestinal epithelium constitutively produces antimicrobial peptides (AMPs) for innate defense.
  • AMP production can be induced and altered during disease states.
  • Knowledge of the complement cascade in the healthy and diseased intestine is limited.

Purpose of the Study:

  • To investigate the interplay between antimicrobial peptides (AMPs) and the complement system in the intestinal mucosa.
  • To explore potential cross-talk mechanisms between AMPs and complement in host defense against microbes.
  • To understand how these systems regulate each other during homeostasis, infection, and inflammation.

Main Methods:

  • Review of existing literature on AMPs and complement in the intestine.
  • Analysis of evidence for complement activation in the intestinal lumen.
  • Examination of findings suggesting epithelial cell involvement in complement pathways, such as anaphylatoxin receptor expression.

Main Results:

  • Epithelial cells produce complement proteins and complement activation occurs in the intestinal lumen.
  • Colonic epithelial cells express anaphylatoxin receptors, indicating a potential for complement signaling.
  • Significant opportunities exist for cross-talk between AMPs and complement in microbial defense and regulation.

Conclusions:

  • There is a need for further research into the collaborative points between AMPs and complement in the gut.
  • Understanding reciprocal control over their expression is crucial for intestinal homeostasis and recovery from inflammation.
  • The interaction between AMPs and complement represents a key area for future investigation in intestinal immunity.