Salmonella-how a metabolic generalist adopts an intracellular lifestyle during infection
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Updated: Apr 17, 2026

Automated Analysis of Intracellular Phenotypes of Salmonella Using ImageJ
Published on: August 9, 2022
Thomas Dandekar1, Astrid Fieselmann1, Eva Fischer1
1Department of Bioinformatics, Biocenter, University of Würzburg Würzburg, Germany.
Abstract:
The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.
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