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Updated: Apr 17, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Turning peptides in comb silicone polymers.

Said Jebors¹, Coline Pinese, Benjamin Nottelet

¹Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 15 avenue Charles Flahault, 34000, Montpellier, France; Institut Charles Gerhardt, UMR5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.

Journal of Peptide Science : an Official Publication of the European Peptide Society

|February 18, 2015

Summary

This summary is machine-generated.

Researchers developed novel silicone-peptide biopolymers using dichloromethylsilane. These polymers feature a polysiloxane backbone with pendant peptide chains and show potential for antibacterial coatings.

Keywords:

comb-polymers hydroxysilyl peptides peptide materials polysiloxane silicone

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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Area of Science:

Materials Science
Polymer Chemistry
Biochemistry

Background:

Silicone-peptide biopolymers offer unique material properties.
Previous work involved di-functionalized chlorodimethylsilyl hybrid peptides.

Purpose of the Study:

To describe a new strategy for synthesizing silicone-peptide biopolymers using dichloromethylsilane.
To investigate the properties and potential applications of these novel polymers.

Main Methods:

Chemoselective polymerization of dichloromethylsilane-derived peptides.
Single-step polymerization under mild conditions (neutral pH, water, room temperature).

Main Results:

Novel polymers with a polysiloxane backbone and pendant peptide chains were synthesized.
Polymerization demonstrated chemoselectivity towards amino acid side chains.
A cationic sequence polymer was successfully prepared and tested.

Conclusions:

A facile and mild method for creating silicone-peptide biopolymers was established.
The synthesized polymers possess desirable characteristics for material applications.
The cationic polymer showed promise for developing antibacterial coatings.