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Updated: Apr 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
The subthalamic nucleus, oscillations, and conflict
Baltazar Zavala1, Kareem Zaghloul, Peter Brown
1Experimental Neurology Group, Nuffield Department of Clinical Neurology, University of Oxford John Radcliffe Hospital, Oxford, UK; Surgical Neurology Branch, National Institutes of Health, Bethesda, MD, USA.
Abstract:
The subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation (DBS) for Parkinson's disease (PD), has received increased attention over the past few years for the roles it may play in functions beyond simple motor control. In this article, we highlight several of the theoretical, interventional, and electrophysiological studies that have implicated the STN in response inhibition. Most influential among this evidence has been the reported effect of STN DBS in increasing impulsive responses in the laboratory setting. Yet, how this relates to pathological impulsivity in patients' everyday lives remains uncertain.
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