Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

5.8K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
5.8K
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

5.5K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
5.5K
Agonism and Antagonism: Quantification01:14

Agonism and Antagonism: Quantification

1.4K
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
1.4K
Oscillations about an Equilibrium Position01:04

Oscillations about an Equilibrium Position

7.3K
Stability is an important concept in oscillation. If an equilibrium point is stable, a slight disturbance of an object that is initially at the stable equilibrium point will cause the object to oscillate around that point. For an unstable equilibrium point, if the object is disturbed slightly, it will not return to the equilibrium point. There are three conditions for equilibrium points—stable, unstable, and half-stable. A half-stable equilibrium point is also unstable, but is named so...
7.3K
Forced Oscillations01:06

Forced Oscillations

8.3K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
8.3K
Brainstem01:19

Brainstem

8.5K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.

Epilepsia·2026
Same author

Response: Temporal encephalocele and epileptogenesis-Reflections of MRI metrics of brain parenchymal tethering.

Epilepsia·2026
Same author

Initial Clinical Experience with the First FDA-Approved sEEG-Guided Radiofrequency Ablation System Featuring Real-Time Temperature Monitoring: A Case Series.

Stereotactic and functional neurosurgery·2026
Same author

Novel magnetic resonance imaging insights from surgically confirmed temporal lobe encephaloceles support tethering as a potential mechanism of epileptogenesis.

Epilepsia·2025
Same author

Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.

medRxiv : the preprint server for health sciences·2025
Same author

SUR1-TRPM4 is expressed in human epilepsy and promotes neuron hyperactivity and seizures in rodents.

Brain : a journal of neurology·2025

Related Experiment Video

Updated: Apr 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K

The subthalamic nucleus, oscillations, and conflict.

Baltazar Zavala1, Kareem Zaghloul, Peter Brown

  • 1Experimental Neurology Group, Nuffield Department of Clinical Neurology, University of Oxford John Radcliffe Hospital, Oxford, UK; Surgical Neurology Branch, National Institutes of Health, Bethesda, MD, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|February 18, 2015
PubMed
Summary

The subthalamic nucleus (STN) is a key deep brain stimulation (DBS) target for Parkinson's disease (PD). Research suggests STN DBS may influence response inhibition, but its real-world impact on impulsivity is unclear.

Keywords:
Parkinson's diseaseconflictdeep brain stimulationimpulsivenesssubthalamic nucleus

More Related Videos

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
10:46

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

16.6K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.6K

Related Experiment Videos

Last Updated: Apr 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K
Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
10:46

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

16.6K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.6K

Area of Science:

  • Neuroscience
  • Neurology
  • Neurosurgery

Background:

  • The subthalamic nucleus (STN) is a primary target for deep brain stimulation (DBS) in Parkinson's disease (PD).
  • Emerging evidence suggests the STN's involvement in cognitive functions, particularly response inhibition, beyond its established motor role.

Purpose of the Study:

  • To review theoretical, interventional, and electrophysiological studies investigating the STN's role in response inhibition.
  • To critically evaluate the link between STN deep brain stimulation (DBS) effects and pathological impulsivity in Parkinson's disease (PD) patients.

Main Methods:

  • Review of existing literature including theoretical models, interventional studies, and electrophysiological research.
  • Analysis of findings from STN deep brain stimulation (DBS) studies, particularly those reporting effects on impulsive behaviors.

Main Results:

  • Studies implicate the subthalamic nucleus (STN) in the neural circuitry of response inhibition.
  • Deep brain stimulation (DBS) of the STN has been associated with increased impulsive responses in laboratory settings.

Conclusions:

  • The subthalamic nucleus (STN) plays a significant role in response inhibition.
  • The clinical relevance of STN deep brain stimulation (DBS)-induced impulsivity changes to everyday pathological impulsivity in Parkinson's disease (PD) patients requires further investigation.