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Role of epigenetic modifications in luminal breast cancer

Hany A Abdel-Hafiz1, Kathryn B Horwitz1,2

  • 1Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA.

Epigenomics
|February 18, 2015
PubMed

Insights

Epigenetic modifications, not just genomic changes, play a key role in endocrine resistance in luminal breast cancer. Targeting these reversible epigenetic changes offers new hope for improving cancer therapy responsiveness.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Luminal breast cancers constitute about 75% of all cases.
  • Endocrine resistance in breast cancer is complex, often linked to genomic alterations.
  • Emerging evidence highlights the significant role of epigenetic modifications in endocrine resistance.

Purpose of the Study:

  • To review the role of epigenetic modifications in endocrine resistance in luminal breast cancer.
  • To explore the potential of targeting epigenetic modifiers for overcoming therapy resistance.

Main Methods:

  • Review of current literature on epigenetic modifications in breast cancer.
  • Analysis of large-scale epigenomic data.
  • Discussion of therapeutic strategies targeting epigenetic modifiers.

Main Results:

  • Epigenetic modifications, including DNA methylation, histone modification, and microRNA alterations, are implicated in endocrine resistance.
  • Distinct epigenomic profiles differentiate breast cancers from normal and benign tissues.
  • Epigenetic modifications are reversible and heritable.

Conclusions:

  • Epigenetic mechanisms are crucial in the development of endocrine resistance in breast cancer.
  • Drugs targeting epigenetic modifiers, used alongside endocrine or chemotherapies, show promise for restoring treatment sensitivity.
Keywords:
breast cancerepigenetic modificationsestrogen receptorsprogesterone receptors

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