Related Experiment Video
Updated: Apr 17, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
Published on: October 19, 2016
Cardiotrophin-1 is associated with increased risk of arterial stiffness
Hao-Chang Hung1, Feng-Hwa Lu, Horng-Yih Ou
1Division of Endocrinology & Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Aim:
Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV).
Methods:
We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s.
Results:
Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise.
Conclusion:
Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.
Related Concept Videos
Coronary Artery Disease I: Introduction
Hypertension II: Pathophysiology
Coronary Artery Disease IV: Preventive Measures
Coronary Artery Disease II: Pathophysiology
Rheumatic Heart Disease I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

