Search research articles

Search research articles

Related Experiment Videos

The interaction between mast cells and endothelial cells.

¹Department of Dermatology, University of Pittsburgh, Pennsylvania.

The Journal of Investigative Dermatology

|August 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of lesional skin c-KIT mutations with clinical phenotype in patients with mastocytosis.

Clinical and experimental dermatology·2018

Same author

Distinct signalling pathways for mutated KIT(V560G) and KIT(D816V) in mastocytosis.

Clinical and experimental dermatology·2013

Same author

Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum.

Clinical and experimental dermatology·2011

Same author

Mastocytosis.

Dermatologic clinics·2001

Same author

New insights into the second generation antihistamines.

Drugs·2001

Same author

B-cell lymphoma in a patient with WHIM syndrome.

Journal of the American Academy of Dermatology·2001

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Mast cells (MCs) interact with endothelial cells (ECs) and nerves, releasing mediators that influence blood vessel permeability, inflammation, and new blood vessel formation. These interactions are crucial in both normal bodily functions and disease processes.

Area of Science:

Immunology
Vascular Biology
Cell Biology

Background:

Mast cells (MCs) are strategically located in tissues, particularly near blood vessels, lymphatics, nerves, and glands.
Their proximity to vascular structures suggests significant interactions with endothelial cells (ECs).

Purpose of the Study:

To explore the multifaceted interactions between mast cells and endothelial cells.
To understand the role of these interactions in physiological and pathological conditions.

Main Methods:

Review of existing literature on mast cell and endothelial cell interactions.
Analysis of mediator release by mast cells and their effects on endothelial cells and nerves.
In vitro studies examining mast cell effects on endothelial cell growth and angiogenesis.

Related Experiment Videos

Main Results:

Mast cells release mediators (histamine, PGD2, leukotrienes) that increase vascular permeability and vasodilation, aiding inflammatory responses.
Mast cell mediators trigger axon reflexes in sensory nerves, releasing neurotransmitters that affect blood vessels and potentially stimulate mast cells.
Mast cells influence endothelial cell proliferation and angiogenesis through mediators like heparin and histamine, and potentially inhibit it via TNF-like peptides.

Conclusions:

Interactions between mast cells and endothelial cells are vital for both normal physiological processes and the development of diseases.
These cellular crosstalks significantly impact vascular tone, permeability, inflammation, and neovascularization.