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Updated: Apr 17, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Formulation design for topical drug and nanoparticle treatment of skin disease
Anthony P Raphael1, Gabriela Garrastazu, Fabio Sonvico
1Dermatology Research Centre, School of Medicine, Translational Research Institute, Princess Alexandra Hospital, The University of Queensland, Level 5 West Wing, 37 Kent Street, Woolloongabba, Brisbane, QLD 4102, Australia.
Abstract:
The skin has evolved to resist the penetration of foreign substances and particles. Topical therapeutic and cosmeceutical delivery is a growing field founded on selectively overcoming this barrier. Both the biology of the skin and the nature of the formulation/active ingredient must be aligned for efficient transcutaneous delivery. This review discusses the biological changes in the skin barrier that occur with common dermatological conditions. This context is the foundation for the discussion of formulation strategies to improve penetration profiles of common active ingredients in dermatology. Finally, we compare and contrast those approaches to recent advances described in the research literature with an eye toward the future of topical formulation design.
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