NF-κB in cancer therapy

Area of Science:

• Oncology
• Molecular Biology
• Biochemistry

Background:

• Nuclear factor kappa B (NF-κB) is a transcription factor implicated in cancer.
• Aberrant NF-κB activation is common in various solid tumors and hematological malignancies.
• NF-κB pathway dysregulation contributes to malignant transformation, proliferation, survival, angiogenesis, invasion, metastasis, and therapeutic resistance.

Purpose of the Study:

• To review the molecular mechanisms of NF-κB pathway activation in human cancers.
• To discuss the role of NF-κB-regulated oncogenic genes in cancer progression.
• To briefly outline pharmacological strategies targeting the NF-κB pathway for cancer therapy.

Main Methods:

• Literature review of studies on NF-κB in cancer.
• Analysis of molecular mechanisms of NF-κB activation.
• Summary of therapeutic approaches targeting NF-κB.

Main Results:

• Constitutive NF-κB activation occurs through diverse mechanisms in different cancers.
• NF-κB-regulated genes play significant roles in oncogenesis and tumor progression.
• Targeting the NF-κB pathway shows therapeutic potential.

Conclusions:

• The NF-κB pathway is a key player in various cancers.
• Understanding NF-κB activation mechanisms is vital for developing targeted cancer therapies.
• Pharmacological inhibition of NF-κB offers a promising therapeutic strategy.