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NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

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Targeted Cancer Therapies

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The Intrinsic Apoptotic Pathway

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Related Experiment Video

Updated: Apr 17, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

NF-κB in cancer therapy.

Feng Li¹, Jingwen Zhang, Frank Arfuso

¹Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute, National University of Singapore, Singapore, 117597, Singapore.

Archives of Toxicology

|February 19, 2015

Summary

Nuclear factor kappa B (NF-κB) signaling is crucial in cancer development, promoting tumor growth and resistance. This review explores NF-κB

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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

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Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Nuclear factor kappa B (NF-κB) is a transcription factor implicated in cancer.
Aberrant NF-κB activation is common in various solid tumors and hematological malignancies.
NF-κB pathway dysregulation contributes to malignant transformation, proliferation, survival, angiogenesis, invasion, metastasis, and therapeutic resistance.

Purpose of the Study:

To review the molecular mechanisms of NF-κB pathway activation in human cancers.
To discuss the role of NF-κB-regulated oncogenic genes in cancer progression.
To briefly outline pharmacological strategies targeting the NF-κB pathway for cancer therapy.

Main Methods:

Literature review of studies on NF-κB in cancer.
Analysis of molecular mechanisms of NF-κB activation.
Summary of therapeutic approaches targeting NF-κB.

Main Results:

Constitutive NF-κB activation occurs through diverse mechanisms in different cancers.
NF-κB-regulated genes play significant roles in oncogenesis and tumor progression.
Targeting the NF-κB pathway shows therapeutic potential.

Conclusions:

The NF-κB pathway is a key player in various cancers.
Understanding NF-κB activation mechanisms is vital for developing targeted cancer therapies.
Pharmacological inhibition of NF-κB offers a promising therapeutic strategy.