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Updated: Apr 17, 2026

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
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Published on: June 29, 2011

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Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death

Yongtao Zhang1, Xiaolei Bi, Fan Jiang

  • 1Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, 107 Wen Hua Xi Road, Jinan, 250012, Shandong Province, China.

Archives of Toxicology
|February 19, 2015
PubMed

Insights

Cytotoxic agents activate NADPH oxidase, influencing cell fate. This enzyme

Area of Science:

  • Cellular biology
  • Biochemistry
  • Toxicology

Background:

  • Cytotoxic agents activate the NADPH oxidase system, regulating cellular functions via redox signaling.
  • NADPH oxidase activation by cytotoxins can lead to either cell survival or cell death.

Purpose of the Study:

  • To summarize evidence on the dual effects of NADPH oxidase on cell fate under cytotoxic stress.
  • To explore the redox signaling mechanisms behind these dichotomous effects.

Main Methods:

  • Literature review of experimental studies on NADPH oxidase activation by cytotoxic agents.
  • Analysis of redox-dependent cellular responses and signaling pathways.

Main Results:

  • NADPH oxidase activation exhibits context-dependent dichotomous effects on cell fate.
  • Redox signaling mechanisms contribute to either cytoprotection or cytotoxicity.

Conclusions:

  • A unified paradigm for NADPH oxidase's toxicological implications is challenging.
  • Interventions targeting NADPH oxidase require stimuli- and cell type-specific approaches.

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