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Related Experiment Video

Updated: Apr 17, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Cerebrovascular neurosurgery 2014.

Mohamed Salem1, Bradley A Gross2, Rose Du2

  • 1Department of Neurological Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|February 19, 2015
PubMed
Summary

In 2014, studies on cerebrovascular disease management revealed no benefit of simvastatin for subarachnoid hemorrhage and mixed results for brain arteriovenous malformations. Familial screening and new endovascular techniques show promise for aneurysm and AVM treatment.

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Area of Science:

  • Neurology and Neurosurgery
  • Vascular Medicine
  • Interventional Neuroradiology

Background:

  • Cerebrovascular disease management is an evolving field with significant clinical impact.
  • Advances in 2014 included randomized trials and long-term follow-ups of previous studies.
  • Understanding the optimal treatment for conditions like brain arteriovenous malformations and aneurysms remains critical.

Purpose of the Study:

  • To review key publications and findings in cerebrovascular disease management from 2014.
  • To highlight significant randomized trials, follow-up studies, and novel procedural techniques.
  • To provide an overview of advancements in treating intracranial vascular malformations and aneurysms.

Main Methods:

  • Review of major published randomized controlled trials, including ARUBA, STASH, ISAT, SAMMPRIS, and JAM.
Keywords:
AneurysmArteriovenous malformationMoyamoyaStroke

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  • Analysis of long-term follow-up data from ISAT and midterm results from the SOLARE study.
  • Inclusion of reports on surgical experience, familial screening benefits, angioscopic endovascular procedures, and bypass techniques.

    • Main Results:

    • The STASH trial found no benefit of simvastatin in patients with aneurysmal subarachnoid hemorrhage.
    • The ARUBA trial and Scottish intracranial vascular malformation study provided contrasting findings on unruptured brain arteriovenous malformation management.
    • Follow-up data from ISAT and SAMMPRIS, along with results from the JAM trial, were reported.
    • Positive outcomes were noted for familial screening, angioscopic endovascular procedures, and modified bypass techniques for complex aneurysms.
    • The largest literature series on coiling large/giant aneurysms and midterm results of the SOLARE study were presented.

    Conclusions:

    • 2014 saw critical updates in the evidence base for cerebrovascular disease management, particularly for aneurysms and arteriovenous malformations.
    • While some interventions like simvastatin showed no benefit, advancements in endovascular techniques and screening offer new therapeutic avenues.
    • Continued research and trial follow-ups are essential for refining treatment strategies in neurovascular care.