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Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
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In-TOX-icating neurogenesis.

Marisa Karow1, Benedikt Berninger2

  • 1Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Munich, Germany Laboratory "Adult Neurogenesis and Cellular Reprogramming", Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.

The EMBO Journal
|February 19, 2015
PubMed
Summary

Tox, a transcription factor known for lymphocyte development, plays a key role in orchestrating early mammalian cerebral cortex development from neural stem cells to neurons and glia.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Mammalian cerebral cortex development involves sequential proliferative and differentiative steps from neural stem cells.
  • The molecular mechanisms governing these early developmental steps are not fully understood.

Purpose of the Study:

  • To investigate the role of the HMG-box transcription factor Tox in early mammalian cerebral cortex development.

Main Methods:

  • The study implicates Tox in early cortical development.

Main Results:

  • Tox, a transcription factor previously recognized for its function in lymphocyte development, is shown to be involved in the early stages of cerebral cortex formation.

Conclusions:

  • Tox is a key molecular player in the early development of the mammalian cerebral cortex, linking its known role in immunity to neurodevelopment.