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Cell-cycle-dependent regulation of androgen receptor function

Yulia Koryakina1, Karen E Knudsen1, Daniel Gioeli2

  • 1Department of MicrobiologyImmunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2-16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USASidney Kimmel Cancer CenterThomas Jefferson University, Philadelphia, Pennsylvania, USACancer Center MemberUniversity of Virginia, Charlottesville, Virginia, USA.

Endocrine-Related Cancer
|February 19, 2015
PubMed
Summary

Androgen receptor (AR) activity in prostate cancer is cell-cycle dependent. Mitotic phosphorylation of AR by CDK1 regulates its localization and transcriptional activity, impacting AR oncogene function.

Keywords:
androgen receptorcell cyclelocalizationmitosisphosphorylation

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