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Kidney cancer, version 3.2015

Robert J Motzer1, Eric Jonasch1, Neeraj Agarwal1

  • 1From Memorial Sloan Kettering Cancer Center; The University of Texas MD Anderson Cancer Center; Huntsman Cancer Institute at the University of Utah; Dana-Farber/Brigham and Women's Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; University of Alabama at Birmingham Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Mayo Clinic Cancer Center; UC San Diego Moores Cancer Center; Moffitt Cancer Center; Stanford Cancer Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; City of Hope Comprehensive Cancer Center; Roswell Park Cancer Institute;University of Washington/Seattle Cancer Care Alliance; Massachusetts General Hospital Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fox Chase Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

Journal of the National Comprehensive Cancer Network : JNCCN
|February 19, 2015
PubMed

Insights

The NCCN Kidney Cancer Guidelines now include axitinib as a first-line treatment for clear cell renal carcinoma. Updates also cover pazopanib for subsequent therapy and follow-up care for renal cell carcinoma patients.

Area of Science:

  • Oncology
  • Clinical Practice Guidelines

Background:

  • The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer treatment.
  • Kidney cancer management involves distinct approaches for clear cell and non-clear cell renal carcinoma.

Purpose of the Study:

  • To summarize recent updates to the NCCN Guidelines for Kidney Cancer.
  • To highlight changes in treatment recommendations and follow-up care.

Main Methods:

  • Review of updated NCCN Guidelines for Kidney Cancer.
  • Analysis of new data supporting treatment recommendations.

Main Results:

  • Axitinib is now recommended as a first-line treatment option for clear cell renal carcinoma.
  • Pazopanib is supported by new data for subsequent therapy in clear cell carcinoma after first-line tyrosine kinase inhibitor treatment.
  • Updated guidelines for the follow-up of renal cell carcinoma patients are included.

Conclusions:

  • The NCCN Guidelines for Kidney Cancer have been updated to reflect the latest evidence.
  • These updates provide clinicians with current recommendations for managing renal cell carcinoma.

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