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Laminar Tendon Composites with Enhanced Mechanical Properties.

Kyle A Alberti1, Jeong-Yun Sun2, Widusha R Illeperuma3

  • 1Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, 02155, USA.

Journal of Materials Science
|February 19, 2015
PubMed
Summary

Bioskiving, a novel technique, creates strong, biocompatible tendon constructs. Crosslinking significantly enhances their mechanical properties, making them promising for tissue engineering applications.

Keywords:
biomaterialscollagenmechanical propertiestendon

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Biocompatible and biodegradable materials are crucial for biomedical applications like rotator cuff repair and vascular grafting.
  • Decellularized tendon offers a promising source for creating such materials.
  • Existing methods for fabricating constructs from decellularized tendon have limitations.

Purpose of the Study:

  • To develop a novel technique called "bioskiving" for creating 2D and 3D constructs from decellularized tendon.
  • To investigate the effect of crosslinking density and fiber orientation on the mechanical properties of these constructs.
  • To compare the mechanical properties of bioskived constructs with those made from reconstituted collagen.

Main Methods:

  • Decellularized tendon was mechanically sectioned into thin slices.
  • These slices were stacked and rolled to create 2D and 3D constructs.
  • The effects of varying crosslinking densities and fiber stacking orientations were analyzed.

Main Results:

  • Crosslinking significantly improved construct strength, with ultimate tensile strength increasing over 20-fold and modulus by nearly 50-fold compared to non-crosslinked samples.
  • The mechanism of mechanical failure was investigated for both crosslinked and non-crosslinked constructs.
  • Bioskived constructs exhibited superior mechanical properties compared to those made from reconstituted collagen.

Conclusions:

  • Laminar tendon composites fabricated using bioskiving demonstrate enhanced strength and organized fiber structure.
  • The ability to achieve transversely isotropic mechanical properties further enhances their utility.
  • These biocompatible and biodegradable materials show significant potential for diverse biomedical and tissue engineering applications.