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Immunotargeting of cancer stem cells

Eliza P Kwiatkowska-Borowczyk1, Agnieszka Gąbka-Buszek2, Jakub Jankowski2

  • 1Department of Cancer Immunology, University of Medical Sciences, Poznan, Poland ; Diagnostic and Immunology Department, Greater Poland Cancer Centre, Poznan, Poland.

Contemporary Oncology (Poznan, Poland)
|February 19, 2015
PubMed

Insights

Targeting cancer stem cells (CSCs) is crucial for eradicating cancer due to their resistance to conventional therapies. Immunotherapies offer a promising approach to eliminate these resilient tumour cells.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Cancer stem cells (CSCs) drive tumour initiation, progression, and resistance to chemo- and radiotherapy.
  • Targeting CSCs is essential for effective cancer eradication.
  • CSCs exhibit specific antigens (e.g., ALDH, CD44, EpCAM, CD133) and immunogenicity, making them amenable to immune-based therapies.

Purpose of the Study:

  • To review promising immunotherapeutic strategies for targeting and eliminating cancer stem cells.
  • To highlight the potential of immune-based approaches in overcoming CSC resistance.

Main Methods:

  • Review of existing literature on CSCs and immunotherapies.
  • Analysis of various immune-targeting modalities including dendritic cells, T cells, pluripotent stem cells, and monoclonal antibodies.

Main Results:

  • CSCs are a critical target for durable cancer remission.
  • Immunotherapies demonstrate potential for targeting CSCs with relatively low toxicity.
  • Specific antigens on CSCs facilitate immune recognition and elimination.

Conclusions:

  • Immune targeting of cancer stem cells represents a promising therapeutic avenue.
  • Further development of immunotherapies is needed to effectively eliminate CSCs and eradicate cancer.
Keywords:
adoptive cell transfercancercancer stem cellsdendritic cellsmonoclonal antibodiestumour immunotherapy

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