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Immune recognition of influenza virus haemagglutinin
J J Skehel1, B C Barnet, D S Burt
1National Institute for Medical Research, Mill Hill, London, U.K.
Abstract:
Haemagglutinin glycoproteins are the components of influenza virus membranes against which infectivity-neutralizing antibodies are directed. Sequence analysis of natural and laboratory-selected variant haemagglutinins indicates the regions of the molecule recognized by antibodies and by helper T cells; the identity of these regions and the relations between them are discussed.