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Updated: Apr 17, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
General analytical procedure for determination of acidity parameters of weak acids and bases
Bogusław Pilarski1, Roman Kaliszan2, Dariusz Wyrzykowski3
1Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland.
Abstract:
The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes. The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture. Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.
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