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Related Experiment Videos

A possible basis for major histocompatibility complex-restricted T-cell recognition.

M M Davis1, Y H Chien, P J Bjorkman

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|June 12, 1989
PubMed
Summary
This summary is machine-generated.

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The T-cell receptor (TCR) delta locus is surprisingly embedded within the TCR alpha locus, linking alpha:beta and gamma:delta heterodimers. This structural arrangement concentrates somatic diversity in the V-J junction, potentially mediating antigen contact.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Four T-cell receptor (TCR) gene loci (alpha, beta, gamma, delta) have been identified.
  • TCR loci rearrange similarly to immunoglobulin genes, forming alpha:beta or gamma:delta TCR-CD3 complexes.

Purpose of the Study:

  • To investigate the relationship between TCR alpha and delta loci.
  • To analyze the diversity and potential function of TCR V-J junctional regions.

Main Methods:

  • Gene locus characterization.
  • Analysis of T-cell receptor diversity and somatic polymorphism.
  • Molecular modeling studies.

Main Results:

  • TCR delta coding regions are located within the TCR alpha locus, sharing V region gene segments.

Related Experiment Videos

  • TCRs exhibit extreme somatic polymorphism in V-J junctions, significantly exceeding immunoglobulins.
  • TCR V region combinations are less numerous than immunoglobulins.

    • Conclusions:

    • The close linkage of TCR alpha and delta loci suggests a shared evolutionary or functional basis.
    • The V-J junctional regions of TCRs likely interact with peptide antigens.
    • Remaining TCR diversity regions may interact with Major Histocompatibility Complex (MHC) molecules.