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Tumor suppression by resistant maltodextrin, Fibersol-2
Eui Young So1, Mutsuko Ouchi, Sara Cuesta-Sancho
1a Department of Cancer Genetics ; Roswell Park Cancer Institute ; Buffalo , NY USA.
Cancer Biology & Therapy
|February 19, 2015
Summary
Fibersol-2, a dietary fiber, was found to inhibit colorectal cancer growth by inducing apoptosis. This safe supplement shows potential for preventing colon cancer development.
Area of Science:
- Oncology
- Gastroenterology
- Nutritional Science
Background:
- Resistant maltodextrin (Fibersol-2) is a soluble, fermentable dietary fiber.
- It is Generally Recognized As Safe (GRAS) in the United States.
- The potential anti-tumor activity of Fibersol-2 requires investigation.
Purpose of the Study:
- To determine if Fibersol-2 possesses anti-tumor properties against human colorectal cancer.
- To elucidate the mechanisms underlying Fibersol-2's potential anti-cancer effects.
Main Methods:
- Human colorectal cancer cell line (HCT116) and isogenic variants were treated with Fibersol-2 in vitro.
- Tumor growth and tumorigenesis were assessed in vivo using tumor xenografts.
- Apoptotic pathways and reactive oxygen species (ROS) generation were investigated.
Main Results:
- Fibersol-2 significantly inhibited HCT116 cell growth by inducing apoptosis.
- It strongly induced mitochondrial ROS and Bax-dependent cleavage of caspase 3 and 9.
- Fibersol-2 modulated Akt and mTOR phosphorylation in a p53/Bax-dependent manner and prevented tumor xenograft growth without toxicity.
Conclusions:
- Fibersol-2 demonstrates significant anti-tumor activity against colorectal cancer cells.
- The mechanism involves ROS generation, apoptosis induction, and modulation of key signaling pathways.
- Fibersol-2 is identified as a potential mechanism-based dietary supplement for colorectal cancer prevention.
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